All serum of cell-box is transported by dry ice in the frozen state, they are directly delivered by the manufacturer to the contracted agent, and then sent to the customer. Cell-Box prohibits any third-party cross-stocking between provinces and cities. Therefore, the serum has not been thawed and will not affect the use effect. However, in order to ensure the benefit of users and the effect of use, it is recommended to purchase serum from a regular contracted agent.